Sialic acid O-acetylation patterns and glycosidic linkage type determination by ion mobility-mass spectrometry
Abstract O-acetylation is a common modification of sialic acids that has been implicated in a multitude of biological ashy bines protein powder and disease processes.A lack of analytical methods that can determine exact structures of sialic acid variants is a hurdle to determine roles of distinct O-acetylated sialosides.Here, we describe a drift tu